CDK5 neutralizes the tumor suppressing effect of BIN1 via mediating phosphorylation of c-MYC at Ser-62 site in NSCLC.

Xiangyu ZhangJiali WangYunlong JiaTianxu LiuMengjie WangWei LvRong ZhangJuan ShiYunlong Jia

Published in: Cancer cell international (2019)

CDK5 blocked the interaction of BIN1 and c-MYC via promoting phosphorylation of c-MYC at ser-62 site, ultimately facilitated the progression of NSCLC.

Keyphrases

small cell lung cancer
cell cycle
advanced non small cell lung cancer
protein kinase
brain metastases
cell proliferation