Neuropsychological Outcome of Critically Ill Patients with Severe Infection.
Maria Della GiovampaolaIrene CavalliLuciana MasciaPublished in: Biomedicines (2022)
Sepsis and septic shock represent important burdens of disease around the world. Sepsis-associated neurological consequences have a great impact on patients, both in the acute phase and in the long term. Sepsis-associated encephalopathy (SAE) is a severe brain dysfunction that may contribute to long-term cognitive impairment. Its pathophysiology recognizes the following two main mechanisms: neuroinflammation and hemodynamic impairment. Clinical manifestations include different forms of altered mental status, from agitation and restlessness to delirium and deep coma. A definite diagnosis is difficult because of the absence of specific radiological and biological criteria; clinical management is restricted to the treatment of sepsis, focusing on early detection of the infection source, maintenance of hemodynamic homeostasis, and avoidance of metabolic disturbances or neurotoxic drugs.
Keyphrases
- septic shock
- cognitive impairment
- acute kidney injury
- early onset
- intensive care unit
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- traumatic brain injury
- cerebral ischemia
- lipopolysaccharide induced
- drug induced
- white matter
- mild cognitive impairment
- combination therapy
- blood brain barrier
- brain injury
- functional connectivity