Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis.
V AndreasiC RicciStefano PartelliG GuarneriC IngaldiF MuffattiS CrippaR CasadeiM FalconiPublished in: Journal of endocrinological investigation (2021)
Disease relapse occurs in approximately one out of five patients submitted to curative surgery for NF-PanNENs. Nodal involvement, tumor grade, microvascular and perineural invasion are relevant prognostic factors, that should be taken into account for follow-up and for possible trials investigating adjuvant or neoadjuvant treatments.
Keyphrases
- prognostic factors
- minimally invasive
- coronary artery bypass
- signaling pathway
- rectal cancer
- lps induced
- lymph node
- end stage renal disease
- oxidative stress
- early stage
- ejection fraction
- nuclear factor
- locally advanced
- newly diagnosed
- neoadjuvant chemotherapy
- squamous cell carcinoma
- radiation therapy
- inflammatory response
- peritoneal dialysis
- immune response