Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence.

Junming BiHongwei LiuWei DongWeibin XieQingqing HeZijian CaiJian HuangTianxin Lin

Published in: Molecular cancer (2019)

These results reveal that Circ-ZKSCAN1 acts as a tumor suppressor via a novel circ-ZKSCAN1/miR-1178-3p/p21 axis, which have the important role in the proliferation, migration and invasion ablitities of BCa cells and provide a novel perspective on circRNAs in BCa progression.

Keyphrases

prognostic factors
induced apoptosis
signaling pathway
cell cycle arrest
genome wide
single cell
endoplasmic reticulum stress
free survival
cell death