Lysophosphatidic acid as a regulator of endometrial connective tissue growth factor and prostaglandin secretion during estrous cycle and endometrosis in the mare.

Anna Z Szóstek-MioduchowskaNatalia LeciejewskaBeata ZelmańskaJoanna Staszkiewicz-ChodorGraça Ferreira-DiasDariusz Skarzynski

Published in: BMC veterinary research (2020)

Our data indicate that endometrosis disturbs proper endometrial function and is associated with altered endometrial LPA concentration, its receptor expression and protein abundance, PGE2/PGF2α ratio, and CTGF secretion in response to LPA. These changes could influence several physiological events occurring in endometrium in mare during estrous cycle and early pregnancy.

Keyphrases

growth factor
endometrial cancer
electronic health record
transcription factor
protein protein
small molecule
machine learning
antibiotic resistance genes
data analysis
deep learning