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LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay.

Mohamed W AttwaAli Saber AbdelhameedNasser S Al-ShakliahAdnan A Kadi
Published in: Drug design, development and therapy (2020)
TND exhibited a moderate extraction ratio indicative of good bioavailability. According to the literature, the approach developed in the present study is the first established LC-MS/MS method for assessing TND metabolic stability.
Keyphrases
  • systematic review
  • high throughput
  • mass spectrometry
  • simultaneous determination
  • high resolution
  • clinical evaluation