LC-MS/MS Estimation of the Anti-Cancer Agent Tandutinib Levels in Human Liver Microsomes: Metabolic Stability Evaluation Assay.
Mohamed W AttwaAli Saber AbdelhameedNasser S Al-ShakliahAdnan A KadiPublished in: Drug design, development and therapy (2020)
TND exhibited a moderate extraction ratio indicative of good bioavailability. According to the literature, the approach developed in the present study is the first established LC-MS/MS method for assessing TND metabolic stability.