Optical genome mapping reveals balanced and unbalanced genetic changes associated with tumor-forming potential in an early-stage prostate cancer epithelial subline (M2205).

Prabakaran PaulrajElizabeth S Barrie Colleen K Jackson-Cook

Published in: Molecular genetics & genomic medicine (2023)

These results support using OGM as a tool to analyze solid tumors in clinical/research settings. Moreover, this OGM analysis expanded the characterization of cytogenetic changes present in the M2205 subline, including alterations associated with tumors from Black males diagnosed with prostate cancer.

Keyphrases

prostate cancer
early stage
radical prostatectomy
high resolution
genome wide
squamous cell carcinoma
gene expression
radiation therapy