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Structural basis for the functional properties of the P2X7 receptor for extracellular ATP.

Lin-Hua JiangEmily A CaseleySteve P MuenchSébastien Roger
Published in: Purinergic signalling (2021)
The P2X7 receptor, originally known as the P2Z receptor due to its distinctive functional properties, has a structure characteristic of the ATP-gated ion channel P2X receptor family. The P2X7 receptor is an important mediator of ATP-induced purinergic signalling and is involved the pathogenesis of numerous conditions as well as in the regulation of diverse physiological functions. Functional characterisations, in conjunction with site-directed mutagenesis, molecular modelling, and, recently, structural determination, have provided significant insights into the structure-function relationships of the P2X7 receptor. This review discusses the current understanding of the structural basis for the functional properties of the P2X7 receptor.
Keyphrases
  • structural basis
  • binding protein
  • crispr cas
  • mass spectrometry
  • high resolution
  • liquid chromatography