Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.
Bin TongLin FuBiao HuZhi-Cheng ZhangZhu-Xia TanSe-Ruo LiYuan-Hua ChenCheng ZhangHua WangDe-Xiang XuHui ZhaoPublished in: BMC pulmonary medicine (2021)
These results provide evidence that TUDCA pretreatment inhibits Smad2/3-medited EMT and subsequent lung fibrosis partially through suppressing BLM-induced ER stress and oxidative stress.