Tauroursodeoxycholic acid alleviates pulmonary endoplasmic reticulum stress and epithelial-mesenchymal transition in bleomycin-induced lung fibrosis.

Bin TongLin FuBiao HuZhi-Cheng ZhangZhu-Xia TanSe-Ruo LiYuan-Hua ChenCheng ZhangHua WangDe-Xiang XuHui Zhao

Published in: BMC pulmonary medicine (2021)

These results provide evidence that TUDCA pretreatment inhibits Smad2/3-medited EMT and subsequent lung fibrosis partially through suppressing BLM-induced ER stress and oxidative stress.

Keyphrases

epithelial mesenchymal transition
endoplasmic reticulum stress
diabetic rats
oxidative stress
induced apoptosis
high glucose
transforming growth factor
signaling pathway
drug induced
dna damage
mouse model
liver fibrosis
pulmonary fibrosis