Transcriptomics of bronchoalveolar lavage cells identifies new molecular endotypes of sarcoidosis.

Milica VukmirovicXiting YanKevin F GibsonMridu GulatiJonas Christian Schupp Giuseppe DeIuliis Taylor Sterling AdamsBuqu HuAntun MihaljinecTony N WoolardHeather LynnNkiruka EmeagwaliErica L HerzogEdward S ChenAlison MorrisJoseph K LeaderYingze Zhang Joe G N GarciaLisa A MaierRonald G CollmanWonder P DrakeMichael J BecichHarry HochheiserSteven R WisniewskiPanayiotis V BenosDavid R MollerAntje PrasseLaura L KothNaftali Kaminskinull null

Published in: The European respiratory journal (2021)

Taken together, our results identify BAL gene expression programmes that characterise major pulmonary sarcoidosis phenotypes and suggest the presence of distinct disease molecular endotypes.

Keyphrases

gene expression
induced apoptosis
cell cycle arrest
dna methylation
pulmonary hypertension
single cell
genome wide
single molecule
cell death