Lomitapide ameliorates middle cerebral artery occlusion-induced cerebral ischemia/reperfusion injury by promoting neuronal autophagy and inhibiting microglial migration.
Yangmin ZhengYue HuZiping HanFeng YanSijia ZhangZhenhong YangFangfang ZhaoLingzhi LiJunfen FanRongliang WangYu-Min LuoPublished in: CNS neuroscience & therapeutics (2022)
Lomitapide is a lipid-lowering drug, and this is the first study to explore its protective effect on ischemic nerve injury in vitro and in vivo. Our results suggest that lomitapide can be repositioned as a potential therapeutic drug for the treatment of stroke.
Keyphrases
- middle cerebral artery
- cerebral ischemia
- signaling pathway
- drug induced
- internal carotid artery
- subarachnoid hemorrhage
- atrial fibrillation
- cell death
- oxidative stress
- high glucose
- inflammatory response
- adverse drug
- diabetic rats
- endoplasmic reticulum stress
- mouse model
- lipopolysaccharide induced
- emergency department
- blood brain barrier
- ischemia reperfusion injury
- peripheral nerve
- spinal cord injury