Phylogenetic Analysis Revealed the Dissemination of Closely Related Epidemic Vibrio cholerae O1 Isolates in Laos, Thailand, and Vietnam.

Masatomo MoritaKazuhisa OkadaTetsu YamashiroTsuyoshi SekizukaAmonrattana RoobthaisongWarawan WongbootSiriporn ChantarojNguyen Dong TuPhonepadith XangsayarathNoikaseumsy SithivongKhambai NoilathArounnapha VongdouangchanhMakoto KurodaShigeyuki HamadaHidemasa IzumiyaMakoto Ohnssishi

Published in: Open forum infectious diseases (2020)

We performed whole-genome sequencing of Vibrio cholerae O1 isolates from Laos, Thailand, and Vietnam, where cholera outbreaks occurred, to determine their genetic lineages. Core genome phylogenetic analysis revealed that the isolates located in same lineage without regional clusters, which suggests that closely related strains circulated in Southeast Asia.

Keyphrases

single cell
genome wide
escherichia coli
genetic diversity
gene expression