Prospective, longitudinal study of cancer predictors and rates in a New York City cohort of 598 patients with acromegaly.

Pamela U Freda Jeffrey N BruceZhezhen JinJane KostadinovAlexander G KhandjiSerge CremersKalmon D Post

Published in: The Journal of clinical endocrinology and metabolism (2024)

Cancer risk is increased in acromegaly, but not in CNFPA patients. Cumulative exposure to IGF-1 excess is a predictor of cancer in acromegaly. Our data suggest that cancer risk in acromegaly relates to the degree and duration of IGF-1 excess and that full appreciation of this risk requires long-term follow up.

Keyphrases

growth hormone
papillary thyroid
end stage renal disease
squamous cell
newly diagnosed
prognostic factors
peritoneal dialysis
binding protein
lymph node metastasis
electronic health record
squamous cell carcinoma
young adults