From man to fly - convergent evidence links FBXO25 to ADHD and comorbid psychiatric phenotypes.

Benjamin HarichMarieke KleinCharlotte W OckeloenMonique van der VoetMarlies Schimmel-NaberNicole de LeeuwAnnette SchenckBarbara Franke

Published in: Journal of child psychology and psychiatry, and allied disciplines (2019)

We combine ADHD risk gene identification in an individual family with genetic association testing in a large case-control data set and functional validation in a model system, together providing an important illustration of an integrative approach suggesting that FBXO25 contributes to key features of ADHD and comorbid neuropsychiatric disorders.

Keyphrases

attention deficit hyperactivity disorder
autism spectrum disorder
working memory
case control
genome wide
copy number
mental health
electronic health record
big data
dna methylation
gene expression
drosophila melanogaster
network analysis