Impact of the Epithelial Lining Fluid Milieu on Amikacin Pharmacodynamics Against Pseudomonas aeruginosa.
Aaron J HeffernanFekade B SimeSazlyna Mohd Sazlly LimSaiyuri NaickerKatherine T AndrewsDavid EllwoodJeffrey LipmanKeith GrimwoodJason A RobertsPublished in: Drugs in R&D (2021)
Our findings indicate that simulating the epithelial lining fluid antagonises amikacin-mediated killing of P. aeruginosa, even at the high concentrations achieved following nebulised administration.