Sodium-glucose cotransporter 2 inhibitors regulate ketone body metabolism via inter-organ crosstalk.
Jin Hee KimMinyoung LeeSoo Hyun KimSo Ra KimByung-Wan LeeEun Seok KangBong Soo ChaJin Won ChoEun Young LeePublished in: Diabetes, obesity & metabolism (2018)
SGLT2i increased systemic and tissue BHB levels by upregulating ketogenic enzymes and transporters in the liver, kidney and intestine, suggesting the integrated physiological consequences for ketone body metabolism of SGLT2i administration.
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