Crenigacestat blocking notch pathway reduces liver fibrosis in the surrounding ecosystem of intrahepatic CCA viaTGF-β inhibition.

Serena MancarellaIsabella GiganteGrazia SerinoElena PizzutoFrancesco DituriMaria F ValentiniJingxiao WangXin ChenRaffaele ArmentanoDiego F CalvisiGianluigi Giannelli

Published in: Journal of experimental & clinical cancer research : CR (2022)

Notch signaling inhibition reduces the peritumoral desmoplastic reaction in iCCA, blocking the TGF-β1 canonical pathway.

Keyphrases

liver fibrosis
climate change
transforming growth factor
epithelial mesenchymal transition