Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats.

Zurina HassanFarah W SuhaimiSurash RamanathanKing-Hwa LingMohamad A EffendyChristian P MüllerHans C Dringenberg

Published in: Journal of psychopharmacology (Oxford, England) (2019)

These data suggest that high doses of mitragynine (5 and 10 mg/kg) cause memory deficits, possibly via inhibition of Ca2+ influx and disruption of hippocampal synaptic transmission and long-term potentiation induction.

Keyphrases

cerebral ischemia
prefrontal cortex
traumatic brain injury
temporal lobe epilepsy
electronic health record
working memory
big data
subarachnoid hemorrhage
brain injury
deep learning
data analysis