The effect of derum (bark of Juglans regia tree) extract on oral mucosa: An in vivo study based on epithelial atypia in rabbit model.

Based on this study, prolonged and frequent use of derum can induce dysplastic changes in rabbit oral mucosa, ranging from mild to moderate dysplasia. Further studies with extended times of exposure of derum to oral mucosa are recommended to document these adverse effects as an evidence base.