Unlocking the direct photocatalytic difluoromethylation of C[double bond, length as m-dash]N bonds.
Alberto F Garrido-CastroAndrea GiniM Carmen MaestroJosé AlemánPublished in: Chemical communications (Cambridge, England) (2020)
The current study presents a direct CF2H radical addition to C[double bond, length as m-dash]N bonds predicated on the photocatalytic activation of commercially available zinc difluoromethanesulfinate. The mild conditions in place lead to impressive structural diversity, as quinoxalinones and dibenzazepines, among others, are successfully functionalized.