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Rab GTPases, Active Members in Antigen-Presenting Cells, and T Lymphocytes.

Nidia Carolina Moreno-CoronaMercedes Piedad de León-BautistaMoises León-JuárezAraceli Hernández-FloresJuan Carlos Barragán-GálvezOrestes López-Ortega
Published in: Traffic (Copenhagen, Denmark) (2024)
Processes such as cell migration, phagocytosis, endocytosis, and exocytosis refer to the intense exchange of information between the internal and external environment in the cells, known as vesicular trafficking. In eukaryotic cells, these essential cellular crosstalks are controlled by Rab GTPases proteins through diverse adaptor proteins like SNAREs complex, coat proteins, phospholipids, kinases, phosphatases, molecular motors, actin, or tubulin cytoskeleton, among others, all necessary for appropriate mobilization of vesicles and distribution of molecules. Considering these molecular events, Rab GTPases are critical components in specific biological processes of immune cells, and many reports refer primarily to macrophages; therefore, in this review, we address specific functions in immune cells, concretely in the mechanism by which the GTPase contributes in dendritic cells (DCs) and, T/B lymphocytes.
Keyphrases
  • induced apoptosis
  • cell migration
  • dendritic cells
  • cell cycle arrest
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • emergency department
  • oxidative stress
  • single molecule
  • health information
  • adverse drug