Sanguinarine triggers intrinsic apoptosis to suppress colorectal cancer growth through disassociation between STRAP and MELK.

Xianling GongZhihong ChenQinrui HanChunhui ChenLinlin JingYawei LiuLiang ZhaoXueqing YaoXue-Gang Sun

Published in: BMC cancer (2018)

Sanguinarine dephosphorelates STRAP and MELK and disassociates the interaction between them to trigger intrinsic apoptosis. Overexpression of STRAP and MELK may be markers of CRC and their disassociation may be a determinant of therapeutic efficacy.

Keyphrases

endoplasmic reticulum stress
oxidative stress
cell cycle arrest
cell death
transcription factor
signaling pathway