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Divergence of variant binding/neutralizing antibodies following SARS-CoV-2 booster vaccines in myeloma: Impact of hybrid immunity.

Alberto C MorenoKelly ManningMaryam I AzeemAjay K NookaMadison EllisRenee Julia ManaloJeffrey M SwitchenkoBushra WaliJonathan L KaufmanCraig C HofmeisterNisha S JosephSagar LonialKavita M DhodapkarMadhav V DhodapkarMehul S Suthar
Published in: bioRxiv : the preprint server for biology (2023)
We characterized virus-neutralization and spike-binding antibody profiles in myeloma patients following monovalent or bivalent-SARS-CoV-2 booster vaccination. Vaccination improves the breadth of binding antibodies but not neutralization activity against current variants. Hybrid immunity and immune imprinting impact vaccine-elicited immunity.
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