Ultrastructural Characteristics of Rat Hepatic Oval Cells and Their Intercellular Contacts in the Model of Biliary Fibrosis: New Insights into Experimental Liver Fibrogenesis.

Joanna Maria Lotowska Maria Elżbieta Sobaniec-ŁotowskaDariusz Marek LebensztejnUrszula DanilukPiotr SobaniecKrzysztof SendrowskiJaroslaw DanilukJoanna Reszec-GielazynWojciech Debek

Published in: Gastroenterology research and practice (2017)

HPC proliferation induced by BDL evidently promotes portal fibrogenesis. Better understanding of the complex cellular interactions between HPCs and adjacent NPCs, especially T-HSCs, may help develop antifibrotic therapies in the future.

Keyphrases

induced apoptosis
signaling pathway
cell cycle arrest
oxidative stress
current status
endoplasmic reticulum stress
cell death
liver fibrosis
cell proliferation