Opposite subgenual cingulate cortical functional connectivity and metabolic activity patterns in refractory melancholic major depression.
Guo-Rong WuRudi De RaedtPeter Van SchuerbeekChris BaekenPublished in: Brain imaging and behavior (2021)
Although in treatment-resistant depression (TRD) subgenual anterior cingulate cortex (sgACC) functional connectivity (FC) is frequently used to examine deregulated brain networks, neurobiological data from other sources may be required to interpret these FC findings. In 16 melancholic TRD patients with a high level of treatment resistance and 16 closely matched healthy never-depressed individuals we verified whether sgACC FC patterns were related to regional metabolic activity (CMRglc) with 18FDG PET imaging. Notwithstanding that TRD patients displayed stronger sgACC FC with the right lateral frontotemporal cortex, metabolically they exhibited the opposite pattern. Our results indicate that the sgACC seed and its functionally connected regions not automatically follow a similar metabolic pattern in TRD, possibly reflecting the refractory state of the sample. Multimodal brain imaging may help to increase our insight into the pathophysiology of TRD.
Keyphrases
- functional connectivity
- resting state
- pet imaging
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- prognostic factors
- peritoneal dialysis
- electronic health record
- pain management
- physical activity
- big data
- machine learning
- pet ct
- sleep quality
- patient reported outcomes
- mass spectrometry
- blood brain barrier
- drug induced
- amyotrophic lateral sclerosis
- photodynamic therapy
- cerebral ischemia
- patient reported