Use of inhaled corticosteroids and risk of acquiring Pseudomonas aeruginosa in patients with chronic obstructive pulmonary disease.
Josefin EklöfTruls Sylvan IngebrigtsenRikke SørensenMohamad Isam SaeedImane Achir AlispahicPradeesh SivapalanJonas Bredtoft BoelJette BangsborgChristian OstergaardRam Benny DessauUlrich Stab JensenEjvind Frausing HansenTherese Sophie LapperreHowraman MeteranTorgny WilckeNiels SeersholmJens-Ulrik Stæhr JensenPublished in: Thorax (2021)
Use of ICS in patients with COPD followed in Danish outpatient clinics was associated with a substantially increased and dose-dependent risk of acquiring P. aeruginosa. Caution should be taken when administering high doses of ICS in severely ill patients with COPD. These results should be confirmed in comparable cohorts and other settings.