Functional phenotyping of the CYP2D6 probe drug codeine in the horse.
S R GretlerC J FinnoP H KassHeather K KnychPublished in: BMC veterinary research (2021)
The MR calculated from plasma following codeine administration allowed for classification of horses into metabolic phenotypes within a large population. The range of codeine metabolism observed among horses suggests the presence of genetic polymorphisms in CYP2D82 of which codeine is a known substrate. Additional studies including CYP2D82 genotyping of high- and low-MR individuals are necessary to determine the presence of CYP2D polymorphisms and their functional implications with respect to the metabolism of therapeutics.