Multimodal mucosal and systemic immune characterization of a non-human primate trachoma model highlights the critical role of local immunity during acute phase disease.
Elodie PauletVanessa ContrerasMathilde GalhautIda RosenkrandsMartin HollandMatthew BurtonJes DietrichAnne-Sophie GallouetNathalie BosquetFrancis RelouzatSébastien LangloisFrank FollmannRoger Le GrandMarc LabetoulleAntoine RousseauPublished in: PLoS neglected tropical diseases (2024)
Our NHP model accurately reproduces the clinical signs of acute trachoma, allowing for an accurate assessment of the local immune responses in infected eyes. A progressive immune response occurred for weeks after exposure to Ct, which subsided into a persistent innate immune response. An understanding of these local responses is the first step towards using the model to assess new vaccine and therapeutic strategies for disease prevention.
Keyphrases
- immune response
- dendritic cells
- toll like receptor
- multiple sclerosis
- endothelial cells
- computed tomography
- optical coherence tomography
- high resolution
- liver failure
- pain management
- image quality
- chronic pain
- hepatitis b virus
- acute respiratory distress syndrome
- intensive care unit
- ulcerative colitis
- induced pluripotent stem cells
- mechanical ventilation
- extracorporeal membrane oxygenation
- cataract surgery