Development of a novel, concentric micro-ECoG array enabling simultaneous detection of a single location by multiple electrode sizes.


Previous studies have compared macro- and microelectrodes for localizing seizure activity in
adjacent regions. The multi-scale design validated here is the first to simultaneously measure
macro- and microelectrode signals from the same overlapping cortical area. This enables direct
comparison of microelectrode recordings to the macroelectrode recordings used in standard
neurosurgical practice. Previous studies have also shown that cortical regions generating
high-frequency oscillations are at an increased risk for becoming epileptogenic zones. More
accurate mapping of these micro seizures may improve surgical outcomes for epilepsy patients.