Curbing Obesity from One Generation to Another: the Effects of Bariatric Surgery on the In Utero Environment and Beyond.
Redin A SpannBernadette E GraysonPublished in: Reproductive sciences (Thousand Oaks, Calif.) (2020)
Approximately 250,000 individuals seek bariatric surgery each year in the USA for the long-term resolution of obesity-related comorbidities. Greater than 80% of these individuals are women and approximately half are of child-bearing age. Although there are many positive metabolic benefits that are realized through surgical weight loss for both men and women, the various long-term hormonal, molecular, nutrient, and epigenetic changes following bariatric surgery have not been evaluated for the surgical recipient or in the context of pregnancy and the offspring. Pregnancy may be a vulnerable period of time for the bariatric surgery recipient, and thoughtful consideration of pregnancy management should be taken by health care providers and recipients alike. The purpose of this review is to explore potential etiologies of some of the gestation-specific outcomes for the mother and offspring.
Keyphrases
- bariatric surgery
- weight loss
- obese patients
- pregnancy outcomes
- roux en y gastric bypass
- gastric bypass
- preterm birth
- healthcare
- polycystic ovary syndrome
- high fat diet
- insulin resistance
- weight gain
- type diabetes
- metabolic syndrome
- pregnant women
- preterm infants
- gene expression
- single molecule
- mental health
- high fat diet induced
- climate change
- skeletal muscle
- human health