Neural Mechanisms That Underlie Angina-Induced Referred Pain in the Trigeminal Nerve Territory: A c-Fos Study in Rats.
Bunsho HayashiMasako MaedaMasayoshi TsuruokaTomio InouePublished in: ISRN Pain (2013)
The present study was designed to determine whether the trigeminal sensory nuclear complex (TSNC) is involved in angina-induced referred pain in the trigeminal nerve territory and to identify the peripheral nerve conducting nociceptive signals that are input into the TSNC. Following application of the pain producing substance (PPS) infusion, the number of Fos-labeled cells increased significantly in the subnucleus caudalis (Sp5C) compared with other nuclei in the TSNC. The Fos-labeled cells in the Sp5C disappeared when the left and right cervical vagus nerves were sectioned. Lesion of the C1-C2 spinal segments did not reduce the number of Fos-labeled cells. These results suggest that the nociceptive signals that conduct vagal afferent fibers from the cardiac region are input into the Sp5C and then projected to the thalamus.
Keyphrases
- neuropathic pain
- induced apoptosis
- peripheral nerve
- chronic pain
- cell cycle arrest
- spinal cord
- pain management
- spinal cord injury
- coronary artery disease
- signaling pathway
- high glucose
- coronary artery
- low dose
- percutaneous coronary intervention
- diabetic rats
- heart failure
- cell death
- climate change
- left ventricular
- atrial fibrillation
- endothelial cells
- postoperative pain
- acute coronary syndrome