EGFR Status Assessment for Better Care of Early Stage Non-Small Cell Lung Carcinoma: What Is Changing in the Daily Practice of Pathologists?
Paul HofmanPublished in: Cells (2021)
The recent emergence of novel neoadjuvant and/or adjuvant therapies for early stage (I-IIIA) non-small cell lung carcinoma (NSCLC), mainly tyrosine kinase inhibitors (TKIs) targeting EGFR mutations and immunotherapy or chemo-immunotherapy, has suddenly required the evaluation of biomarkers predictive of the efficacy of different treatments in these patients. Currently, the choice of one or another of these treatments mainly depends on the results of immunohistochemistry for PD-L1 and of the status of EGFR and ALK. This new development has led to the setup of different analyses for clinical and molecular pathology laboratories, which have had to rapidly integrate a number of new challenges into daily practice and to establish new organization for decision making. This review outlines the impact of the management of biological samples in laboratories and discusses perspectives for pathologists within the framework of EGFR TKIs in early stage NSCLC.
Keyphrases
- small cell lung cancer
- early stage
- epidermal growth factor receptor
- advanced non small cell lung cancer
- tyrosine kinase
- healthcare
- decision making
- end stage renal disease
- single cell
- primary care
- brain metastases
- quality improvement
- cell therapy
- ejection fraction
- physical activity
- newly diagnosed
- chronic kidney disease
- photodynamic therapy
- lymph node
- peritoneal dialysis
- prognostic factors
- cancer therapy
- squamous cell carcinoma
- radiation therapy
- patient reported outcomes
- stem cells
- pain management
- mesenchymal stem cells