Sequence of Alzheimer disease biomarker changes in cognitively normal adults: A cross-sectional study.

Jingqin LuoFolasade AgboolaElizabeth GrantColin L MastersMarilyn S AlbertSterling C JohnsonEric M McDadeJonathan VögleinAnne M FaganTammie BenzingerParinaz MassoumzadehJason HassenstabRandell J BatemanJohn C MorrisRichard J PerrinJasmeer ChhatwalMathias JuckerBernardino GhettiCarlos CruchagaNeill R Graff-RadfordPeter R SchofieldHiroshi MoriChengjie Xiong

Published in: Neurology (2020)

Our findings support the hypothesized early changes of amyloid in preclinical AD and suggest that changes in neuronal injury and neurodegeneration markers occur close in time to cognitive decline.

Keyphrases

cognitive decline
mild cognitive impairment
physical activity
cell therapy
risk factors
stem cells
cerebral ischemia
blood brain barrier
bone marrow