In vivo tau pathology is associated with synaptic loss and altered synaptic function.
Emma M CoomansDeborah N SchoonhovenHayel TuncelSander C J VerfaillieEmma E WoltersRonald BoellaardRik OssenkoppeleAnouk den BraberWiep ScheperPatrick SchoberSteven P SweeneyJ Michael RyanRobert C SchuitAlbert D WindhorstFrederik BarkhofPhilip ScheltensSandeep S V GollaArjan HillebrandAlida A GouwBart N M van BerckelPublished in: Alzheimer's research & therapy (2021)
These results indicate that in Alzheimer's disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction.