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In vivo tau pathology is associated with synaptic loss and altered synaptic function.

Emma M CoomansDeborah N SchoonhovenHayel TuncelSander C J VerfaillieEmma E WoltersRonald BoellaardRik OssenkoppeleAnouk den BraberWiep ScheperPatrick SchoberSteven P SweeneyJ Michael RyanRobert C SchuitAlbert D WindhorstFrederik BarkhofPhilip ScheltensSandeep S V GollaArjan HillebrandAlida A GouwBart N M van Berckel
Published in: Alzheimer's research & therapy (2021)
These results indicate that in Alzheimer's disease, tau pathology is closely associated with reduced synaptic density and synaptic dysfunction.
Keyphrases
  • prefrontal cortex
  • oxidative stress
  • cognitive decline
  • mild cognitive impairment