LRRC15 promotes osteogenic differentiation of mesenchymal stem cells by modulating p65 cytoplasmic/nuclear translocation.

Yuejun WangYunsong LiuMin ZhangLongwei LvXiao ZhangYongsheng ZhouYongsheng Zhou

Published in: Stem cell research & therapy (2018)

Taken together, our findings reveal that LRRC15 is an essential regulator for osteogenesis of MSCs through modulating p65 cytoplasmic/nuclear translocation, and give a novel hint for MSC-mediated bone regeneration.

Keyphrases

bone regeneration
mesenchymal stem cells
umbilical cord
signaling pathway
bone marrow
genome wide
transcription factor
single cell
gene expression