"Molecular analysis of the rare S-s- red blood cell phenotype in blood donors and patients in south-east Brazil".

Flávia Leite Souza SantosTalitha Baldin CuterEvandra Strazza RodriguesÊmile Cristina BettarelloEugenia Maria Amorim UbialiLilian Maria CastilhoSimone KashimaDimas Tadeu Covas

Published in: Vox sanguinis (2019)

GYPB deletion is the main mechanism responsible for the S-s- phenotype in our donors and patients. It is essential to evaluate the main GYPB variant alleles when genotyping in order to obtain the correct prediction of the phenotype. Hybrid genes lead to discrepancies between genotype and phenotype and may not be detected by conventional molecular assays.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
red blood cell
chronic kidney disease
prognostic factors
peritoneal dialysis
high throughput
gene expression
patient reported outcomes