The Soft Coral Sarcophyton trocheliophorum : A Warehouse of Terpenoids with Structural and Pharmacological Diversity.
Qi-Bin YangQihao WuJun-Kun ChenLin-Fu LiangPublished in: Marine drugs (2022)
The soft coral Sarcophyton trocheliophorum , which was frequently encountered on Indo-Pacific and Red Sea coral reefs, furnished a wealth of secondary metabolites. Notably, terpenoids dominated the chemical profile of this species. In this review, we summarized the discovery of 156 terpenoids from the soft coral S. trocheliophorum specimens in different geographical areas. The structures comprised 13 terpenoidal classes with various functionalities. We covered the era from the first report of S. trocheliophorum -derived metabolites in 1976 up to October 2022. The biological effects of these chemical compositions on a vast array of potential pharmacological activities such as protein tyrosine phosphatase 1B (PTP1B) inhibitory, neuroprotective, cytotoxic, anti-inflammatory, antibacterial, antivirus, and immunomodulatory activities were also presented. This review also revealed an immense demand to explore the terpene biosynthetic gene clusters of this species besides the chemo- and bio-investigations.
Keyphrases
- risk assessment
- anti inflammatory
- ms ms
- high resolution
- high throughput
- small molecule
- photodynamic therapy
- genome wide
- single cell
- mass spectrometry
- gene expression
- copy number
- drug delivery
- protein protein
- dna methylation
- climate change
- locally advanced
- blood brain barrier
- cancer therapy
- binding protein
- cerebral ischemia