Impact of obesity on chemotherapy dosing of carboplatin and survival of women with ovarian cancer.
Alexandra L MartinChristelle M Colin-LeitzingerSweta K SinhaJing-Yi ChernLauren C PeresPublished in: British journal of cancer (2023)
In the real-world setting, underdosing of carboplatin in the neoadjuvant setting was associated with inferior survival among women with serous tumours. With the increasing utilisation of neoadjuvant chemotherapy in EOC, actual weight-based dosing of carboplatin may be important to improve outcomes in this patient population.
Keyphrases
- locally advanced
- phase ii study
- neoadjuvant chemotherapy
- rectal cancer
- squamous cell carcinoma
- radiation therapy
- weight loss
- sentinel lymph node
- weight gain
- lymph node
- insulin resistance
- high grade
- free survival
- body mass index
- type diabetes
- phase iii
- case report
- physical activity
- high fat diet induced
- clinical trial
- open label