Decarboxylative halogenation of indoles by vanadium haloperoxidases.
Lauren J HarstadClare E WellsHyung Ji LeeLauren P T RamosManik SharmaCameron A PascoeKyle F BiegasiewiczPublished in: Chemical communications (Cambridge, England) (2023)
Halogenated heteroarenes are key building blocks across numerous chemical industries. Here, we report that vanadium haloperoxidases are capable of producing 3-haloindoles through decarboxylative halogenation of 3-carboxyindoles. This biocatalytic method is applicable to decarboxylative chlorination, bromination, and iodination in moderate to high yields and with excellent chemoselectivity.