Combination of monensin and erlotinib synergistically inhibited the growth and cancer stem cell properties of triple-negative breast cancer by simultaneously inhibiting EGFR and PI3K signaling pathways.

Tian FangShiheng HuXinhao SongJunqi WangRunan ZuoShifeng YunShanxiang JiangDawei Guo

Published in: Breast cancer research and treatment (2024)

The simultaneous inhibition of the EGFR/ERK and PI3K/AKT/mTOR signaling pathways by the combination of monensin and erlotinib exhibited a synergistic effect on suppressing tumor proliferation and cancer cell stemness in TNBC.

Keyphrases

signaling pathway
epidermal growth factor receptor
cancer stem cells
epithelial mesenchymal transition
advanced non small cell lung cancer
tyrosine kinase
pi k akt
small cell lung cancer
induced apoptosis
stem cells
cell proliferation