B-cell ALL with SOX11 gene amplification associates with a worse outcome.
George AngelakakisMallika VarkhediToriana R DabkowskiMichael J DiazMichelle YeagleyGeorge BlanckPublished in: Cell cycle (Georgetown, Tex.) (2024)
Copy number variation (CNV) of certain genes in pediatric Acute Lymphoblastic Leukemia (ALL) impacts gene expression levels. Here, we aimed to investigate the potential prognostic utility of CNVs in pediatric B-ALL and T-ALL. Using genomics files representing cases from the TARGET-ALL-P2 dataset, genes commonly involved in ALL development were analyzed for CNVs. Case IDs representing increased copy numbers for SOX11 , PDGFRB , and MDK represented a worse overall survival probability specifically for B-ALL (logrank p=0.021, p=0.0052, p=0.019, respectively). These data support the continued investigation of using CNVs for clinical prognostic biomarkers for pediatric B-ALL.
Keyphrases
- copy number
- genome wide
- acute lymphoblastic leukemia
- gene expression
- mitochondrial dna
- dna methylation
- genome wide identification
- transcription factor
- stem cells
- genome wide analysis
- big data
- acute myeloid leukemia
- risk assessment
- single cell
- artificial intelligence
- electronic health record
- deep learning
- data analysis