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Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19.

Sarah AdamoStéphane ChevrierCarlo CerviaYves ZurbuchenMiro E RaeberLiliane YangSujana SivapathamAndrea JacobsEsther BaechliAlain RudigerMelina Stüssi-HelblingLars C HuberDominik J SchaerBernd BodenmillerOnur BoymanJakob Nilsson
Published in: Allergy (2021)
Our study suggests that severe COVID-19 is characterized by extensive T cell dysfunction and T cell apoptosis, which is associated with signs of homeostatic T cell proliferation and T cell recovery.
Keyphrases
  • cell proliferation
  • coronavirus disease
  • sars cov
  • early onset
  • cell cycle
  • oxidative stress
  • intellectual disability
  • respiratory syndrome coronavirus
  • signaling pathway