CDHu40: a novel marker gene set of neuroendocrine prostate cancer (NEPC).

Sheng LiuHye Seung NamZiyu ZengXuehong DengElnaz PashaeiYong ZangLei YangChenglong LiJiaoti HuangMichael K WendtXin LuRong Huang Jun Wan

Published in: bioRxiv : the preprint server for biology (2024)

our study integrates gene expression variances in multiple NEPC studies and protein-protein interaction network to pinpoint a specific set of NEPC maker genes namely CDHu40. These genes and scores based on their gene expression levels effectively distinguish NEPC samples and underscore the clinical prognostic significance and potential mechanism.

Keyphrases

gene expression
protein protein
genome wide
prostate cancer
dna methylation
genome wide identification
small molecule
genome wide analysis
radical prostatectomy
bioinformatics analysis
copy number
transcription factor
risk assessment