Gold(I)-Coumarin-Caffeine-Based Complexes as New Potential Anti-Inflammatory and Anticancer Trackable Agents.
Audrey TrommenschlagerFlorian ChotardBenoît BertrandSouheila AmorPhilippe RichardAli BettaïebCatherine PaulJean-Louis ConnatPierre Le GendreEwen BodioPublished in: ChemMedChem (2018)
Three new gold(I)-coumarin-based trackable therapeutic complexes and two non-trackable analogues have been synthesised and fully characterised. They all display anti-proliferative properties on several types of cancer cell lines, including those of colon, breast, and prostate. Two complexes displayed significant anti-inflammatory effects; one displayed pro-inflammatory behaviour; this highlights the impact of the position of the fluorophore on the caffeine scaffold. Additionally, the three coumarin derivatives could be visualised in vitro by two-photon microscopy.
Keyphrases
- fluorescent probe
- living cells
- anti inflammatory
- prostate cancer
- papillary thyroid
- high resolution
- single molecule
- silver nanoparticles
- structure activity relationship
- optical coherence tomography
- high throughput
- high speed
- mass spectrometry
- squamous cell carcinoma
- tissue engineering
- young adults
- lymph node metastasis
- label free