Antibody therapy can enhance AngiotensinII-induced myocardial fibrosis.

Nicole L RosinAlison J GareauDevin BetschAlec FalkenhamMryanda J SopelTimothy Dg LeeJean-Francois Légaré

Published in: Fibrogenesis & tissue repair (2014)

These data suggest that myocardial fibrosis was increased by the addition of exogenous non-specific antibodies in an Fc-mediated manner. These findings could have substantial impact on the future experimental design of antibody-based therapeutics.

Keyphrases

left ventricular
high glucose
diabetic rats
electronic health record
small molecule
liver fibrosis
big data
stem cells
drug induced
heart failure
mesenchymal stem cells
machine learning
oxidative stress
atrial fibrillation
replacement therapy