Change in volumetric tumor growth rate after cytotoxic therapy is predictive of overall survival in recurrent glioblastoma.
Sonoko OshimaAkifumi HagiwaraCatalina RaymondChencai WangNicholas S ChoJianwen LuBlaine S C EldredPhioanh Leia NghiemphuAlbert LaiDonatello TelescaNoriko SalamonTimothy F CloughesyBenjamin M EllingsonPublished in: Neuro-oncology advances (2023)
A decrease in TGR in patients with PFS6, along with smaller baseline tumor volume, were associated with a significantly longer OS in rGBM treated with chemotherapy with or without radiation. Importantly, all patients that exhibited PFS6 also showed a measurable decrease in TGR.