Role of Senescent Cells in Cutaneous Wound Healing.
Allison M AndradeMingda SunNathan S GasekGeneva R HargisRoshanak SharafiehMing XuPublished in: Biology (2022)
Cellular senescence has gained increasing attention in the field of aging research. Senescent cells have been implicated in biological aging processes, tumorigenesis, development, and wound repair amongst other processes and pathologies. Recent findings reveal that senescent cells can both promote and inhibit cutaneous wound healing processes. Relating senescent cells in acute and chronic wounds will help to clarify their role in wound healing processes and inform our understanding of senescent cell heterogeneity. To clarify this apparent contradiction and guide future research and therapeutic development, we will review the rapidly growing field of cellular senescence and its role in wound healing biology.
Keyphrases
- wound healing
- induced apoptosis
- cell cycle arrest
- dna damage
- single cell
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- cell death
- signaling pathway
- gene expression
- computed tomography
- magnetic resonance imaging
- cell proliferation
- pi k akt
- dna methylation
- working memory
- genome wide
- hepatitis b virus
- drug induced
- acute respiratory distress syndrome
- extracorporeal membrane oxygenation
- respiratory failure
- mechanical ventilation