Novel Variants and Copy Number Variation in CDH1 Gene in Iranian Patients with Sporadic Diffuse Gastric Cancer.
Abbas MoridniaMohammad Amin TabatabaiefarMehrdad ZeinalianMohammad MinakariMajid KheirollahiNoushin Afshar MoghaddamPublished in: Journal of gastrointestinal cancer (2020)
Our study revealed several novel somatic variants in the CDH1 gene in Iranian patients with sporadic diffuse GC. Our data supports the hypothesis that mutations in CDH1 gene, and particularly the mutations we describe, should be considered, even in sporadic cases of gastric cancer. The presence of these mutations in patients raises important issues regarding genetic counseling and diagnostic test in DGC patients.
Keyphrases
- copy number
- mitochondrial dna
- genome wide
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- late onset
- dna methylation
- prognostic factors
- peritoneal dialysis
- amyotrophic lateral sclerosis
- electronic health record
- machine learning
- human immunodeficiency virus
- mass spectrometry
- patient reported