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B-cell lymphoma extra-large (Bcl-xL) is a promising drug target in Merkel cell carcinoma.

Kaiji FanNalini SrinivasLinda KubatJan GravemeyerAntje SuckerDirk SchadendorfThilo GambichlerJürgen Christian Becker
Published in: The British journal of dermatology (2023)
Bcl-xL, which is highly expressed in MCC, appears to be an attractive therapeutic target for the treatment of this tumor; especially since the effect of specific Bcl-xL inhibitors is synergistically enhanced by simultaneous PARP inhibition.
Keyphrases
  • dna damage
  • diffuse large b cell lymphoma
  • dna repair