Essential role of the CCL2-CCR2 axis in Mayaro virus-induced disease.
Franciele Martins SantosVictor Rodrigues de Melo CostaSimone de AraújoCarla Daiane Ferreira de SousaThaiane Pinto MoreiraMatheus Rodrigues GonçalvesAnna Clara Paiva Menezes Dos SantosHeloísa Athayde Seabra FerreiraPedro Augusto Carvalho CostaBreno Rocha BarrioniPaula Bargi-SouzaMarivalda de Magalhães PereiraMaurício Lacerda NogueiraDanielle da Glória SouzaPedro Pires Goulart GuimarãesMauro Martins TeixeiraCelso Martins Queiroz-JuniorVivian Vasconcelos CostaPublished in: Journal of virology (2024)
mice was associated with high levels of CCL2, an important chemoattractant involved in the recruitment of macrophages, the main precursor of osteoclasts. In the absence of the CCR2 receptor, there is a mitigation of macrophage migration to the target organs of infection and protection of these mice against bone loss induced by MAYV infection. Much evidence has shown that host immune response factors contribute significantly to the tissue damage associated with alphavirus infections. Thus, this work highlights molecular and cellular targets involved in the pathogenesis of arthritis triggered by MAYV and identifies novel therapeutic possibilities directed to the host inflammatory response unleashed by MAYV.
Keyphrases
- bone loss
- inflammatory response
- immune response
- dendritic cells
- high fat diet induced
- liver injury
- drug induced
- rheumatoid arthritis
- regulatory t cells
- liver fibrosis
- climate change
- oxidative stress
- adipose tissue
- diabetic rats
- toll like receptor
- type diabetes
- gene expression
- wild type
- insulin resistance
- metabolic syndrome
- skeletal muscle
- lps induced
- dna methylation
- binding protein